Analytical Techniques

07 AUG. 2024

This article is only available in English.

Chromatography

Liquid Chromatography 
Identification, assay and impurity profiling of chemical entities. High or ultrahigh performance liquid chromatography coupled to ultraviolet/visible, refractive index or mass spectrometry detection. 
• Gas chromatography 
Gas chromatography with flame ionization detection for residual solvent analysis, and for identification, assay and impurity profiling of volatile chemical entities. 
• Thin layer Chromatography 
Identification of chemical entities and their impurities, in simple and complex matrices. 

Spectrometry

• Ultraviolet and visible spectrophotometry 
Identification and assay of chemical entities. 
• Infrared spectrophotometry 
Identification of chemical entities by FTIR with transmission or absorption recording. 
 

Basic chemical testing

• Titrimetry 
Assay by amperometric, potentiometric or complexometric titration. 
• Water Content 
Coulometry and Karl Fischer titration. 
• Loss on drying 
• Identification reactions of ions and functional groups 
• Potentiometric determination of pH 
• Clarity and degree of opalescence of liquids 
• Degree of coloration of liquids 
• Osmolarity 
• Relative density 
• Refractive index 
• Optical rotation 

Pharmacotechnical testing

• Disintegration 
For tablets, capsules, suppositories and pessaries. 
• Unity of dosage units 
• Dissolution test 
Dissolution rate for conventional-, prolonged- or delayed-release solid dosage forms with a basket or paddle apparatus. 
• Friability 
• Resistance to crushing 

Biological testing

• Sterility 
Membrane filtration or direct inoculation. 
• Microbiological examination of non-sterile products  
Microbial enumeration is applied to quantify aerobic bacteria and fungi. The presence of specific micro-organisms is tested by growth on an appropriate medium and under specific conditions. Automated microbial identification based on biochemical testing. 
• Bacterial endotoxins 
Detection and quantification by the gel-clot or chromogenic method. 
• Assay of heparins 
Determination of the anticoagulant activity of heparins. 

Herbal testing

• Micro- and macroscopy 
Identification and foreign matter. 
• Liquid chromatography 
Identification and assay of active substances and markers. High or ultrahigh performance liquid chromatography coupled to ultraviolet/ visible, fluorescence, refractive index or mass spectrometry detection. 
• Gas chromatography 
Chromatographic profile of essential oils. 
• Thin-layer chromatography 
Identification of active substances and markers. 
• Ultraviolet and visible spectrophotometry 
Colorimetry of active substances and markers. 
• Determination of essential oils 
• Microbiological examination 
Microbiological enumeration and testing for specified micro-organisms in herbal medicinal products for oral use and extracts. 

The list of our accredited techniques is available on request or can be consulted here.

Charlotte Matthys

Lab Admin Manager Stuur een e-mail +32(0)2 285 42 52

Phasius

Toon alles

Uit onze klantentevredenheidsenquêtes over 2023 blijkt dat de meeste klanten ons een perfecte score van 10/10 geven.

Extensive expertise in product quality and patient safety

Het zoeken naar betrouwbaar, gepersonaliseerd deskundig advies over de kwaliteit en veiligheid van geneesmiddelen of andere gezondheids- en verzorgingsproducten is vaak een complex proces. Verlies geen tijd meer: doe een beroep op Phasius.

Door de ontwikkeling, optimalisering en validering van analytische methoden toe te vertrouwen aan een betrouwbare partner die gespecialiseerd is in dit domein, kunt u de ontwikkelingstijd van uw producten aanzienlijk verkorten en de time-to-market versnellen.

Sinds hun oprichting zijn kwaliteitscontroleanalyses de core business van de APB-laboratoria. Door al uw kwaliteitscontroleprojecten aan Phasius toe te vertrouwen, kiest u voor veiligheid, eenvoud en betrouwbaarheid!